Glucose fluctuations in association with oxidative stress among children with type 1 diabetes mellitus: comparison of different phases

Methods Children treated for T1DM at Beijing Children’s hospital from 2010 to 2013 were enrolled and divided EQUALLY into three study groups including newly diagnosed children (Group A, acute metabolic disturbance phase), Group B (honeymoon phase), and Group C (long-standing phase). Healthy control children were matched to the T1DM patients by age and sex. The 24-hour urinary free 8-iso-prostaglandin F2a to creatinine (8-isoPGF2a/Cr) ratio indicated oxidative stress. Glucose fluctuation parameters (GFPs) included mean blood glucose levels (MBG), standard deviation of daily blood glucose levels (SDBG), mean amplitude of glucose excursions (MAGE), and incremental area under the curve for postprandial glucose (IAUC). GFPs and 8-isoPGF2a/Cr levels in the study groups were compared and the association of GFPs and 8-isoPGF2a/Cr across groups was assessed.